Yazar "0000-0002-5315-253X" için Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Anti-Inflammatory and Anti-Fibrotic Effects of Ursodeoxycholic Acid in Streptozocin-Induced Diabetic Rats
Canbolat, İsmail Polat; Yiğittürk, Gürkan; Erbaş, Oytun (Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2020)INTRODUCTION: Diabetic cardiomyopathy is a consequence of free fatty acid oxidation, dysfunction in mitochondria, oxidative stress and diffuse myocardial fibrosis. We aimed to investigate the anti-inflammatory and anti-fibrotic ... -
Anticancer activity of linalool: comparative investigation of ultrastructural changes and apoptosis in breast cancer cells
Elbe, Hülya; Öztürk, Feral; Yiğittürk, Gürkan; Baygar, Tuba; Çavuşoğlu, Türker (TAYLOR & FRANCIS INC, 2022)Breast cancer is the most common cancer in women in the world. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Linalool is aromatic compounds from ... -
Cardio-protective effect of dapagliflozin against doxorubicin induced cardiomyopathy in rats
Belen, E.; Canpolat, I. P.; Yiğittürk, Gürkan; Çetinarslan, Ö. (VERDUCI PUBLISHER, 2022)OBJECTIVE: Cancer is the second most common non-communicable disease group in the world and its frequency is increasing. In parallel, side effects of drugs used in cancer treatment are frequently encountered. Doxorubicin ... -
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology
Özkul, Bahattin; Sever, İbrahim Halil; Yiğittürk, Gürkan; Elgörmüş, Çağrı Serdar; Gür, Seray Gizem; Erbaş, Oytun (Turkish Association of Trauma and Emergency Surgery (TATES), 2023)Background: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate ... -
Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy
Karahan, Gökhan; Kaya, Hüseyin; Eyceyurt, Recep Selçuk; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun (Spandidos Publications, 2021)The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ... -
Effect of fl uid resuscitation on acute lung injury in a rat model of sepsis
Erdoğan, A.; Erdoğan, M. A.; Kara, A. Y.; Bora, S.; Gürkan Yiğittürk; Erbaş, O. (COMENIUS UNIV, 2021)AIM: Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taşkın, Banu; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Alper, Sibel; Erbaş, Oytun (Hindawi, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gürkan, Gökhan; Erdoğan, Mümin Alper; Karahan, Gökhan; Kaya, Hüseyin; Yiğittürk, Gürkan (Turkish Neurosurgical Society, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
INVESTIGATION OF URSODEOXYCHOLIC ACID EFFECTS ON SIROLIMUS TREATED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
Arısu Naghavi, Esra; Tekeli, Senem; Uynaıkgil, Yiğit; Göker Bağca, Bakiye; Yiğittürk, Gürkan; Gökçe, Burak; Tomruk, Canberk; Çavuşoğlu, Türker; Biray Avcı, Çığır; Gündüz, Cumhur (Süleyman Demirel Üniversitesi, 2022)Objective The usage of mesenchymal stem cells (MSC) with immunosuppressive drugs after organ transplantation is becoming remarkable in clinical applications. However, the drugs negatively affect MSCs. Ursodeoxycholic acid ... -
Is losartan a promising agent for the treatment of type 1 diabetes-induced testicular germ cell apoptosis in rats?
Buhur, Aylin; Gürel, Çevik; Kuşçu, Gökçe Ceren; Yiğittürk, Gürkan; Oltulu, Fatih; Karabay Yavaşoğlu, Nefise Ülkü; Uysal, Ayşegül; Yavaşoğlu, Altuğ (Springer Science and Business Media B.V., 2022)Background: Diabetes mellitus (DM) is common metabolic disease that poses a major risk to public health and fertility. Previous studies indicate that DM may cause male infertility by triggering oxidative stress and germ ... -
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease
Yigittürk, Gürkan; Bilal, Burçin; Kirazlar, Mehmet; Erdoğan, Mümin Alper; Erbaş, Oytun (Journal of Chemical Neuroanatomy, 2023)Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is ... -
Leptin Accelerates Endothelial Wound Healing: Role of Endothelial Nitric Oxide Synthase Expression
Yiğittürk, Gürkan; Önal, Melike Özgül; Subaşı, Ekin; Doğan, Beyza; Türkmenoğlu, Melih; Kaplan, Merve; Yaşar, Volkan; Elbe, Hülya; Öztürk, Feral; 0000-0002-5315-253X (Turkish Society of Cardiology, 2022)Background: The endothelium is crucial for the control of vascular homeostasis and plays a role in angiogenesis. Leptin, a protein released mainly by adipose tissue, plays a key role in the regulation of energy balance and ... -
The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy
Yiğittürk, Gürkan; Erbaş, Oytun; Karabay Yavaşoğlu, Nefise Ülkü; Açıkgöz, Eda; Buhur, Aylin (Taylor and Francis Ltd., 2021)Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. ... -
Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats
Biçer, Yasemin; Elbe, Hülya; Karayakalı, Melike; Yigittürk, Gürkan; Yılmaz, Ümit; Cengil, Osman; Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp (Elsevier B.V., 2022)The current study aimed to evaluate the neuroprotective effect of exogenous melatonin against acrylamide (ACR)-induced oxidative stress and inflammatory and apoptotic responses in the brain tissues in pinealectomized rats ... -
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun; Taşkıran, Dilek (TAYLOR & FRANCIS INC, 2021)Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ... -
Oxidative stress-induced apoptotic changes after acute exposure to antifouling agent zinc pyrithione (ZnPT) in Mytilus galloprovincialis Lamark (Mediterranean mussels) tissues
Kataloay, Selma; Güner, Adem; Dağdeviren, Melih; Yiğittürk, Gürkan; Yavaşoğlu, Altuğ; Günal, A. Çağlan (TAYLOR & FRANCIS LTD, 2022)Zinc pyrithione (ZnPT) is one of the components used in antifouling paints and can be an alternative to classical toxic chemicals such as organotin. However, there is still remarkable concern about the environmental safeness ... -
Phytochemistry, Biological Activity and Toxicity of Botanical Dietary Supplement: KL21
Kösal Karayıldırım, Çinel; Güner, Adem; Yiğittürk, Adem; Yavaşoğlu, Altuğ; Yavaşoğlu Karabay, N. Ülkü (Celal Bayar Üniversitesi, 2022)The use of nutritional supplements has grown conspicuously over the last decades. The present study aimed to design, develop, and optimize the toxicological and biological procedures to perform the quantitative determination ... -
Platelet-Rich Plasma in Vitrification; is it Helpful or Harmful?
Çavuşoǧlu, Türker; Gökhan, Aylin; Tomruk, Canberk; Şirin, Cansın; Kılıç, Kubilay Doǧan; Yiǧittürk, Gürkan (University of Agriculture, 2023)Human and animal studies on cryoprotectants and freezing solutions are still needed to establish a simple yet reliable protocol and increase the success of cryopreservation. The main aim of this study was to evaluate the ... -
Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats
Biçer, Ahmet; Erçin, Burak Sercan; Gürler, Tahir; Yiğittürk, Gürkan; Uyanıkgil, Yiğit; Çetin, Emel Öykü (Taylor and Francis Ltd., 2021)Introduction: Extravasation injuries are one of the most feared complications of intravenous drug administration. The most common drugs associated with extravasation injury include chemotherapy agents and contrast media. ...