Association between platelet indices and first trimester miscarriage

Abstract

We aimed to measure the effect of several potential risk factors on first trimester miscarriage. A total of 169 cases were included in the present study. Patients were selected from women who had first trimester miscarriage (n = 78) and controls were selected from the women who had given birth at term (> 37 weeks of gestation) to healthy infants (n = 91). Compared with the control group, in the miscarriage group gestational age (8.9 +/- 2.8 weeks and 8.1 +/- 2.2 weeks, respectively, P = 0.032), mean platelet volume (MPV) (8.8 +/- 1 and 9.5 +/- 1.1 fl, respectively, P < 0.001), plateletcrit (0.209 +/- 0.03% and 0.241 +/- 0.05%, respectively, P < 0.001), and platelet/lymphocyte ratio (128 +/- 37 and 145 +/- 60, respectively, P = 0.027) were significantly higher. Multivariate analysis showed that first trimester miscarriage development ratio was 1.909 times higher when MPV value was over 9.1 fl (P < 0.001); 9.147 times higher when plateletcrit value was over 0.219% (P = 0.022). Receiver operating characteristic analysis was performed to determine diagnostic MPV and plateletcrit values for first trimester miscarriage. MPV value greater than 9.1 fl determined miscarriage with 60% sensitivity and 65% specificity, while plateletcrit value greater than 0.219% determined miscarriage with 64.5% sensitivity and 64.7% specificity. MPV and plateletcrit values were strongly associated with first trimester miscarriage. Platelet indices can be used for prediction of fetal loss. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.