Fluorescent supramolecular tweezers for selective recognition of cephradine

Abstract

Novel supramolecular molecular tweezers based on a biphenyl bis-triazole hexahydroquinoline system are designed and synthesized as a highly sensitive and selective fluorescent probe for recognizing and detecting cephradine in the presence of cefotaxime, amoxicillin, penicillin, 6-.aminopenicillanic acid, diclofenac, pefloxacin, ceftriaxone, cefaclor and paracetamol at a pH of 7.7. The detection limit is calculated to be 1 mu M with a regression coefficient of 0.99. The binding ratio of the tweezers and cephradine is determined to be 1:1 according to ESI-MS analysis, which is further supported by the Job plot. The structure of the supramolecular molecular tweezers and its precursors are characterized by IR, NMR, mass spectroscopy and XRD. (C) 2014 Elsevier Ltd. All rights reserved.