Triterpenoid saponins from the roots of two Gypsophila species
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Tarih
2014Yazar
Pertuit, DavidAvunduk, Sibel
Mitaine-Offer, Anne-Claire
Miyamoto, Tomofumi
Tanaka, Chiaki
Paululat, Thomas
Lacaille-Dubois, Marie-Aleth
Üst veri
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Two triterpenoid saponins with two known ones have been isolated from the roots of Gypsophila arrostii var. nebulosa, and two new ones from the roots of Gypsophila bicolor. Their structures were established by extensive NMR and mass spectroscopic techniques as 3-O-beta-D-galactopyranosyl-(12)-[beta-D-xylopyranos yl-(1 -> 3)]-beta-D-glucuronopyranosylquillaic acid 28-O-beta-D-xylopyranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 3)]-alpha-L-rhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)]-beta-D-fucopyranosyl ester (1), 3-O-beta-D-ogalactopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucuronopyranosylgypsogenin 28-O-beta-D-xylop yranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 3)]-alpha-L-rhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)]-beta-D-fucopyranosyl ester (2), 3-O-beta-D-galactopyranosyl-(1 -> 3)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucurono pyranosylgypsogenin 28-O-beta-D-xylopyranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 2)-[(4-O-acetyl)-beta-D-quinovopyranosyl-(1 -> 4)]-beta-D-fucopyranosyl ester (3), gypsogenic acid 28-O-beta-D-glucopyranosyl-(1 -> 3)]-{6-O-[3-hydroxy-3-methylglutaryl]-beta-D-glucopyranosyl-(1 -> 6)}-beta-D-galactopyranosyl ester (4). Three compounds were evaluated against one human colon cancer cell line SW480 and one rat cardiomyoblast cell line H9c2. (C) 2014 Elsevier Ltd. All rights reserved.