Antioxidant Diterpenoids from the Roots of Salvia barrelieri

Abstract

Introduction - The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities. Objective - The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the antioxidant activity. Methodology - Chromatographic methods were used for fractionation and isolation, respectively. Structure elucidation was established by spectroscopic methods. Five antioxidant assays were performed. Results - Three new abietane diterpenoids barreliol, royleanone 12-methyl ether and 7-epi-saiviviridinol, and six known diterpenoids, with a known dammarane triterpenoid, pyxinol were isolated. The absolute stereochemistry of pyxinol was confirmed by X-ray analysis. Conclusion - Taxodione exhibited the highest antioxidant activity among the tested compounds. Copyright (c) 2009 John Wiley & Sons, Ltd.