Investigation of inflammatory response at blood-poly (2-methoxyethyl acrylate) (PMEA) interface in vivo via scanning tunneling microscope

Abstract

The effects of an amphiphilic polymer coating of poly(2-methoxyethyl acrylate) (PMEA) on immunoglobulin adsorption and leukocyte adhesion were investigated. Forty patients were operated on using noncoated and PMEA-coated oxygenator fibers; leukocyte counts adhered onto the noncoated and coated fibers. It appears that the adsorbed immunoglobulin on noncoated fiber surfaces plays a role in leukocyte adhesion and complement activation by an alternative pathway, while the PMEA coating reduced the complement activation on the oxygenator hollow fibers. The biomaterial and blood interaction at the interface could potentially be used as an indicator for predicting the artificial devices long-term clinical performance.